Study Links Menopause Hormones to Structural Changes Affecting Memory and Mood

New research strongly suggests that the menopause transition causes measurable physical changes in the brain’s structure, which may explain common symptoms like “brain fog,” mood swings, and memory issues.

One of the most consistent patterns identified by the Puerto Rico-based researchers was a decrease in gray matter volume during the menopause transition. Gray matter is vital for day-to-day functioning and its reduction is linked to cognitive decline.

While the structural changes are real, experts caution against panic. Medical professionals emphasize there is no clear evidence that the temporary “brain fog” experienced during the menopause transition is directly associated with a later risk of dementia.

Despite this reassurance, doctors suggest that the loss of neuroprotective estrogen during menopause could potentially contribute to susceptibility to Alzheimer’s disease 10 to 20 years later, highlighting the importance of continued research into hormone-based therapies.